Molecular hinges

Biomimetic entropy-dominant molecular hinges with picomolar affinity

Supramolecular ‘retinal-opsin’: host-induced entropy-dominant molecular hinges with ultrahigh binding affinity are devised to mirror the natural retinal-opsin cycle. J. Am. Chem. Soc. (2024)

Zehuan Huang, Alexander S. Groombridge, Guanglu Wu, Magdalena Olesinska, Xiaoyi Chen, Jade A. McCune, Oren A. Scherman